Prof. Dr Md Jamal Uddin
CO releasing molecule-2 protects acute kidney injury through HO-1-mitochondrial fitness in mice
Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, South Korea.
ABSTRACT
Mitochondrial injury is regarded as a hallmark of acute kidney injury (AKI), while carbon monoxide (CO) rescues mice from lethal sepsis by supporting mitochondrial energetics, and biogenesis. Thus, the present study investigated the kidney protective mechanism of CO releasing molecule2 (CORM2) focusing on mitochondrial dysfunction. Male C57BL/6J mice were administrated with LPS (15 mg/kg) to induce AKI, and preventive as well as therapeutic effects of CORM2 (30 mg/kg) were determined. Also, the role of heme oxygenase-1 (HO-1) in renoprotection of CORM2 was determined utilizing hemin (HO-1 inducer) and ZnPP (HO-1 inhibitor) in proximal tubular epithelial (mProx) cells. Administration of LPS induced kidney injury, oxidative stress, inflammation, and mitochondrial dysfunction in mice. CORM2 showed not only preventive but also therapeutic effect on LPS-induced kidney injury, oxidative stress, inflammation, and mitochondrial dysregulation in mice. Interestingly, both preventive and therapeutic treatment of CORM2 increased HO-1 expression and its related genes in AKI mice. CORM2 or hemin also attenuated LPS-induced oxidative stress, inflammation, and mitochondrial dysregulation in mProx cells, while pharmacological inhibition of HO-1 using ZnPP abrogated CORM2 or hemin effects. These results demonstrate that CORM2 may protect AKI in mice through HO-1-mitochondrial fitness.
Keywords: AKI, carbon monoxide, mitochondrial fitness, HO-1.
Biography : Dr. Uddin is currently working as Research Professor at Ewha Womans University, South Korea since 2015. He is working on molecular mechanisms involved with various diseases and therapeutic strategies.
Dr. Uddin has accomplished his PhD in 2013, Postdoc in 2015, and Senior Scientist position in 2015 on Biological Sciences from the University of Ulsan, South Korea. He has completed his BSc and MS degree in the discipline of Animal Science, Bangladesh Agricultural University, Bangladesh in 2005. During 2005-2009, he worked at various prestigious institutes like Bangladesh Livestock Research Institute (BLRI), Bangladesh; Gyeongsang National University, South Korea; and so on.
Dr. Uddin received the Korea Research Fellowship (KRF) at the National Research Foundation (NRF) of Korea (grant No. 2015H1D3A1062189). Recently, he also has received the most prestigious Brain Pool (BP) Fellowship at the National Research Foundation of Korea (grant No. 2020H1D3A2A02110924). Since 2005, Dr. Uddin has been working in the area of biotechnology, biomedical sciences, pharmacology, and reproductive biology. Importantly, he is a founder and Co-Editor-in-Chief at the Journal of Advanced Biotechnology and Experimental Therapeutics (Scopus indexed and enlisted in PubMed) and working as a reviewer in various peer-reviewed international journals.
Dr. Uddin is the founder and CEO at ABEx Bio-Research Center, a concern of ABEx Bio (the non-profit company of Bio-Research and health). The feature of these organizations is to connect and collaborate with active and expert scientists in various fields of Bio-Research. Notably, ABEx Bio-Research Center has published 31 articles and is working on more than 15 reviews/original articles on recent findings with the co-operation of 20 PhD holders who are working worldwide and 45 Honor’s final year or MS students as a volunteer research assistant from different universities in Bangladesh.
Dr. Uddin is the founder and publication secretary of BSMIAB. Also, he was the general secretary of 1st BSMIAB-COB International Conference on COVID-19 Pandemic, 06-08 November 2020, Dhaka organized by BSMIAB and community of biotechnology. Besides, Dr. Uddin is also an active member of the Korean Society of Molecular and Cellular biology (KSMCB) since 2010.
Dr. Uddin’s wish is to work where more brainstorming is required rather than simply robotic experiments. He has published more than 75 scientific articles in high impact journals (pharmacology area) including American Journal of Physiology-Endocrinology and Metabolism, Aging cell, Antioxidants, Biomarkers, Biomedicine & Pharmacotherapy, Cancers, Cellular and Molecular Immunology, Environmental Science and Pollution Research, Free Radical Biology and Medicine, Frontiers in Cell and Developmental Biology, Frontiers in Pharmacology, Journal of Pharmacology and Experimental Therapeutics, Immunology Letters, Marine drugs, Nutrients, Phytotherapy Research, Toxics, and so on.